2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154490
    5-(Furan-2-yl)-2’-O-methyl-5’-O-DMTr-uridine
    5-(Furan-2-yl)-2’-O-methyl-5’-O-DMTr-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-(Furan-2-yl)-2’-O-methyl-5’-O-DMTr-uridine
  • HY-152809
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(furan-2-yl)purine
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(furan-2-yl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(furan-2-yl)purine
  • HY-152360
    1-(β-D-Xylofuranosyl)-5-methylcytosine
    1-(β-D-Xylofuranosyl)-5-methylcytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    1-(β-D-Xylofuranosyl)-5-methylcytosine
  • HY-152627
    N6-Methyl-2’-beta-C-ethynyl adenosine
    N6-Methyl-2’-beta-C-ethynyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. N6-Methyl-2’-beta-C-ethynyl adenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N6-Methyl-2’-beta-C-ethynyl adenosine
  • HY-W777033
    Tegafur-13C,15N2
    Tegafur-13C,15N2 (FT 207-13C,15N2) is the 13C- and 15N-labeled Tegafur (HY-17400). Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU proagent used in the treatment of cancers; is a component of tegafur-uracil.
    Tegafur-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-154256
    5-(2-Azidoethyl)uridine
    5-(2-Azidoethyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5-(2-Azidoethyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5-(2-Azidoethyl)uridine
  • HY-152353
    3’-Azido-3’-deoxy-2-thiouridine
    3’-Azido-3’-deoxy-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-2-thiouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxy-2-thiouridine
  • HY-154239
    5’-O-Triphenylmethyl-2’-deoxyuridine
    5’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-Triphenylmethyl-2’-deoxyuridine
  • HY-154361
    TLR7 agonist 13
    TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TLR7 agonist 13
  • HY-113225S1
    Guanosine triphosphate-13C10,15N5 tetraammonium
    Guanosine triphosphate-13C10,15N5 (tetraammonium) is the 13C and 15N labeled Guanosine triphosphate tetraammonium. Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> tetraammonium
  • HY-153059
    5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine
    5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine is a nucleoside compound.
    5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine
  • HY-154024
    N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine
    N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine
  • HY-152375
    8-Hydroxy-xyloguanosine
    8-Hydroxy-xyloguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Hydroxy-xyloguanosine
  • HY-138584
    IBU-DC Phosphoramidite
    IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.
    IBU-DC Phosphoramidite
  • HY-152475
    2’-β-C-Ethynyladenosine
    2’-β-C-Ethynyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2’-β-C-Ethynyladenosine
  • HY-152594
    Uridine-5-oxyacetic acid
    Uridine-5-oxyacetic acid is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Uridine-5-oxyacetic acid
  • HY-154307
    4′,5′-Didehydro-5′-deoxy-2′-O-methyluridine
    4′,5′-Didehydro-5′-deoxy-2′-O-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4′,5′-Didehydro-5′-deoxy-2′-O-methyluridine
  • HY-152540
    5-Methoxy-4-thiouridine
    5-Methoxy-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxy-4-thiouridine
  • HY-154148
    N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine
    N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine
  • HY-152505
    5-Methyl-4-thiouridine
    5-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methyl-4-thiouridine